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N.S. Sikhayeva

National Centre for Biotechnology, 13/1, Valikhanov str., Astana, 000001, Kazakhstan
L.N. Gumilev Eurasian National University, 5, Munaitpasov str, Astana, 000001, Kazakhstan

А.А. Iskakova

National Centre for Biotechnology, 13/1, Valikhanov str., Astana, 000001, Kazakhstan

А.М. Aitkulova

National Centre for Biotechnology, 13/1, Valikhanov str., Astana, 000001, Kazakhstan

Е.V. Zholdybayeva

National Centre for Biotechnology, 13/1, Valikhanov str., Astana, 000001, Kazakhstan

K.T. Momynaliev

National Centre for Biotechnology, 13/1, Valikhanov str., Astana, 000001, Kazakhstan

Е.М. Ramanculov

National Centre for Biotechnology, 13/1, Valikhanov str., Astana, 000001, Kazakhstan


For understanding genetic predisposition to sports activities it is necessary to pay  attention to some genes, such as ACTN3, PPARD, LPL, EDN1, MMP3, INSIG2, PPARGC1A, APOE, SHBG, COL5A1, LEPR, LOXL1, PTPN22, TRAF1. Polymorphisms of these genes are associated with muscular strength, endurance, muscle fiber size and composition. Genetic differences in any of these genes can influence athletic performance. The allele frequency of these genes have been well studied in the European population, but the population of Central Asia has not been extensively studied. It should be noted that the allele frequency may depend on race and ethnicity. The frequency of alleles and genotypes of 19 SNPs were obtained in the Kazakh population (n = 365). The allele frequency (MAF – Minor Allele Frequency) of investigated genes for the Kazakh population were as follows: rs1815739 (С>T) 0,47; rs2016520 (T>C) 0,24; rs328 (C>G) 0,07; rs5370 (G>T) 0,29; rs679620 (С>T) 0,47; rs7566605 (C>G) 0,38; rs8192678 (С>T) 0,52; rs429358 (T>C) 0,14; rs7412 (C>T) 0,05; rs10033464 (G>T) 0,30; rs6258 (C>T) 0,18; rs12722 (C>T) 0,41; rs2025804 (A>G) 0,50; rs2165241 (C>T) 0,38; rs2200733 (C>T) 0,31; rs2476601 (G>A) 0,05; rs3761847 (A>G) 0,48; rs5934505 (T>C) 0,34; rs6457617 (T>C) 0,48.


single nucleotide polymorphism, allele frequency, sports genetic, genotype distribution

Article Details


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